This silicone gel contains aloe vera 0.3% and verapamil HCl 10%. This dual-action gel is available by prescription in a 30 g pump.

This combination is formulated in a silicone gel, and is formulated to support the care of both new and old scars. It contains a blend of silicones in a semipermeable polymer network and pracaxi oil, which is rich in skin-friendly fatty acids and lipids. The formula promotes a soothing and nurturing environment while providing long-lasting moisturization that protects the skin barrier and helps reduce water loss. Patients have used this silicone gel to help improve the appearance of scars, including keloid and acne scars.

Aloe vera (Aloe barbadensis) supports scar management through anti-inflammatory, moisturizing, and wound-healing effects, with evidence showing accelerated healing in second-degree burns [1]. It promotes wound contraction and epithelialization, increases collagen and glycosaminoglycans, and enhances tissue strength and elasticity [2], while also supporting barrier function and hydration [3]. Clinical studies demonstrate reduced water loss, smoother texture, and greater patient satisfaction with aloe vera compared to other topical options [4], making it a safe and cost-effective adjunct for scar care.

Topical verapamil hydrochloride reduces scar formation by blocking calcium influx into fibroblasts, which decreases collagen synthesis, increases collagen breakdown, and supports remodeling in hypertrophic and keloid scars. It also reduces fibroblast density, and limits angiogenesis, further improving scar appearance [5]. Clinical studies show verapamil-containing silicone gel lowers scar elevation and fibroblast counts [5, 6].

Silicone gel creates a semi-occlusive barrier, increases stratum corneum hydration, and alters cytokine-mediated signaling from keratinocytes to fibroblasts [7].

This silicone gel may be considered by providers treating patients who are concerned with scar appearance.

Scars develop as part of the wound healing process and vary by how the skin repairs itself. Hypertrophic scars are raised but remain within the wound boundaries and are linked to excessive extracellular matrix (ECM) deposition [8, 9]. Keloid scars extend beyond the original wound and can continue to grow, often recurring despite treatment. Atrophic scars appear sunken or depressed, commonly after acne or infections [10, 11]. Contracture scars tighten the skin and may restrict movement, especially after burns, while stretch marks (striae) occur when skin stretches rapidly, such as during pregnancy or weight gain. These scar types reflect disruptions in collagen synthesis, degradation, and remodeling, which shape their final appearance [8, 10, 12].

Aloe vera and verapamil have been investigated for their role in scar management, particularly in hypertrophic scars and keloids. Verapamil-containing silicone gel has demonstrated significant improvements in scar elevation index, fibroblast count, and capillary count in a rabbit ear model [13], and clinical studies show verapamil can improve scar appearance with fewer adverse effects compared to corticosteroid injections [14, 15]. Aloe vera cream has been shown to significantly reduce scar formation following surgery, with improved PSAQ and VSS scores in a randomized controlled trial [16]. Additionally, a silicone gel sheet with verapamil microparticles effectively inhibited hypertrophic scar formation in a rabbit model [17]. Together, these findings support the use of aloe vera and verapamil in silicone-based formulations as a promising option for managing raised and post-surgical scars.

1. PRESCRIBER & PATIENT INFORMATION

Prescribing clinician’s name, licensing information, address and contact information. Patients’ full name, date of birth, shipping address and contact information.

2. COMPLETE PRESCRIPTION INFORMATION

Include: drug, dosage, and dosage form, quantity, SIG, and refills if requested.

3. PRESCRIPTION TRANSMITTAL

Fax: (940) 382-2694
Phone: 940-382-6758 | Speak to a pharmacist
Escribe ID: 0903012660 or CARIE BOYD Pharmaceuticals

•  Select Medication from the drop-down menu (bulk ingredient or powder is OK)
•  Use the words Please Compound in the SIG or Comments section followed by the compounded medication you want to prescribe.

NOTE: If you cannot find the same strength or form, that’s OK, write exactly what you want into the SIG or Comments section. In most cases we’ll be able to custom compound the prescribed medication.

Store at controlled room temperature. Protect from light and freezing.

[1] Sharma S, Alfonso AR, Gordon AJ, Kwong J, Lin LJ, Chiu ES. Second-Degree Burns and Aloe Vera: A Meta-analysis and Systematic Review. Adv Skin Wound Care. 2022 Nov 1;35(11):1-9. doi: 10.1097/01.ASW.0000875056.29059.78. PMID: 36264753.
[2] Oryan A, Mohammadalipour A, Moshiri A, Tabandeh MR. Topical Application of Aloe vera Accelerated Wound Healing, Modeling, and Remodeling: An Experimental Study. Ann Plast Surg. 2016 Jan;77(1):37-46. doi: 10.1097/SAP.0000000000000239. PMID: 25003428.
[3] Hekmatpou D, Mehrabi F, Rahzani K, Aminiyan A. The Effect of Aloe Vera Clinical Trials on Prevention and Healing of Skin Wound: A Systematic Review. Iran J Med Sci. 2019 Jan;44(1):1-9. PMID: 30666070; PMCID: PMC6330525.
[4] Bagheri M, Werres M, Fuchs PC, Seyhan H, Lefering R, Grieb G, Schiefer JL. Which Moisturizer to Use in Scar Therapy after Burn Injuries? A Subjective and Objective Skin and Scar Evaluation after Topical Treatment with Dexpanthenol, Aloe Vera, and Plant Oil. Medicina (Kaunas). 2023 Oct 21;59(10):1874. doi: 10.3390/medicina59101874. PMID: 37893592; PMCID: PMC10608183.
[5] Choi J, Han YN, Rha EY, Kang HJ, Kim KJ, Park IK, Kim HJ, Rhie JW. Verapamil-containing silicone gel reduces scar hypertrophy. Int Wound J. 2021 Oct;18(5):647-656. doi: 10.1111/iwj.13566. Epub 2021 Mar 17. PMID: 33733593; PMCID: PMC8450805.
[6] Boggio RF, Boggio LF, Galvão BL, Machado-Santelli GM. Topical verapamil as a scar modulator. Aesthetic Plast Surg. 2014 Oct;38(5):968-75. doi: 10.1007/s00266-014-0400-9. Epub 2014 Sep 5. PMID: 25189298.
[7] Mustoe TA. Evolution of silicone therapy and mechanism of action in scar management. Aesthetic Plast Surg. 2008 Jan;32(1):82-92. doi: 10.1007/s00266-007-9030-9. Epub 2007 Oct 30. PMID: 17968615.
[8] Kidzeru EB, Lebeko M, Sharma JR, Nkengazong L, Adeola HA, Ndlovu H, P Khumalo N, Bayat A. Immune cells and associated molecular markers in dermal fibrosis with focus on raised cutaneous scars. Exp Dermatol. 2023 May;32(5):570-587. doi: 10.1111/exd.14734. Epub 2023 Feb 20. PMID: 36562321; PMCID: PMC10947010.
[9] Pym K. Identifying and managing problem scars. Br J Nurs. 2006 Jan 26-Feb 8;15(2):78-82. doi: 10.12968/bjon.2006.15.2.20367. PMID: 16493282.
[10] Moon J, Yoon JY, Yang JH, Kwon HH, Min S, Suh DH. Atrophic acne scar: a process from altered metabolism of elastic fibers and collagen fibers based on transforming growth factor-β1 signaling. Br J Dermatol. 2019 Dec;181(6):1226-1237. doi: 10.1111/bjd.17851. Epub 2019 Jul 9. PMID: 30822364.
[11] Fabbrocini G, Annunziata MC, D’Arco V, De Vita V, Lodi G, Mauriello MC, Pastore F, Monfrecola G. Acne scars: pathogenesis, classification and treatment. Dermatol Res Pract. 2010;2010:893080. doi: 10.1155/2010/893080. Epub 2010 Oct 14. PMID: 20981308; PMCID: PMC2958495.
[12] Chawla S, Ghosh S. Regulation of fibrotic changes by the synergistic effects of cytokines, dimensionality and matrix: Towards the development of an in vitro human dermal hypertrophic scar model. Acta Biomater. 2018 Mar 15;69:131-145. doi: 10.1016/j.actbio.2018.01.002. Epub 2018 Jan 10. PMID: 29330036.
[13] Choi J, Han YN, Rha EY, Kang HJ, Kim KJ, Park IK, Kim HJ, Rhie JW. Verapamil-containing silicone gel reduces scar hypertrophy. Int Wound J. 2021 Oct;18(5):647-656. doi: 10.1111/iwj.13566. Epub 2021 Mar 17. PMID: 33733593; PMCID: PMC8450805.
[14] Wang R, Mao Y, Zhang Z, Li Z, Chen J, Cen Y. Role of verapamil in preventing and treating hypertrophic scars and keloids. Int Wound J. 2016 Aug;13(4):461-8. doi: 10.1111/iwj.12455. Epub 2015 May 12. PMID: 25968157; PMCID: PMC7949878.
[15] Ahuja RB, Chatterjee P. Comparative efficacy of intralesional verapamil hydrochloride and triamcinolone acetonide in hypertrophic scars and keloids. Burns. 2014 Jun;40(4):583-8. doi: 10.1016/j.burns.2013.09.029. Epub 2013 Oct 31. PMID: 24182692.
[16] Kaboodkhani R, Sarikhani M, Kazemi T, Zarshenas MM, Shahrizi MM, Sadati MS, Owji SH. The Effects of Aloe Vera Cream on the Alar Scar in Rhinoplasty, A Randomized Double-Blind Controlled Trial. Iran J Otorhinolaryngol. 2024 May;36(3):499-505. doi: 10.22038/IJORL.2024.77572.3601. PMID: 38745686; PMCID: PMC11090095.
[17] Rha EY, Kim YH, Kim TJ, Yoo G, Rhie JW, Kim HJ, Park IK. Topical Application of a Silicone Gel Sheet with Verapamil Microparticles in a Rabbit Model of Hypertrophic Scar. Plast Reconstr Surg. 2016 Jan;137(1):144-151. doi: 10.1097/PRS.0000000000001889. PMID: 26710018.